AA amyloidosis

AA amyloidosis
Classification and external resources
ICD-10 E85
ICD-9 277.3
DiseasesDB 16
eMedicine med/3388

AA amyloidosis is a form of amyloidosis associated with serum amyloid A protein (SAA), an acute-phase protein.[1] It causes reactive systemic amyloidosis, as a "reaction" to inflammation, but also familial Mediterranean fever, which is an inheritable condition.[2]

Presentation

The common feature to conditions associated with reactive systemic amyloidosis is long-standing cell breakdown due to chronic inflammatory or disease processes.

Associated conditions

It is associated with chronic inflammatory conditions, including: rheumatoid arthritis, ankylosing spondylitis, Crohn disease, ulcerative colitis, tuberculosis, bronchiectasis, chronic osteomyelitis.

Other conditions include Hodgkin disease, renal cell carcinoma.

It can be associated with nephrotic syndrome.[3]

References

  1. ^ Lachmann HJ, Goodman HJ, Gilbertson JA, et al. (June 2007). "Natural history and outcome in systemic AA amyloidosis". N. Engl. J. Med. 356 (23): 2361–71. doi:10.1056/NEJMoa070265. PMID 17554117. 
  2. ^ Chapter 5 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7.  8th edition.
  3. ^ "BU". http://www.bu.edu/amyloid/doctors/features/clinical-aa.html. 
Common amyloid forming proteins
Systemic amyloidosis
Organ-limited amyloidosis